Timme-Laragy publishes review of the regulation and responses of redox status during embryonic development in vertebrates

University of Massachusetts Amherst Assistant Professor of Environmental Health Sciences Alicia Timme-Laragy

Alicia Timme-Laragy

October 11, 2017

Assistant Professor of Environmental Health Sciences Alicia Timme-Laragy is the lead author of an article that has been recently published in Seminars in Cell & Developmental Biology. The article was co-authored by doctoral students Monika Roy (Environmental Health Sciences) and Archit Rastogi (Molecular & Cellular Biology), along with Mark E. Hahn of the Woods Hole Oceanographic Institute and Jason M. Hansen of Brigham Young University.

The article, titled “Redox stress and signaling during vertebrate embryonic development: Regulation and responses,” reviews the importance of redox status in the development of vertebrate embryos. Their analysis looked at multiple levels in which redox signaling and redox stress impacted cell, tissue, and organ development. Timme-Laragy and co-authors conclude that as understanding of the role of redox signaling in developing embryos is advanced, it will lead to “insights into the mechanisms by which redox signaling can be disrupted by developmental exposure to chemicals”.

This review contributes to the work Timme-Laragy has done on embryonic exposure to oxidative stress and its health significance later in life. Last year, the Environmental Health Sciences faculty member was awarded a five-year grant from the National Institute of Environmental Health Sciences to research how oxidative stress from toxicants at the early stages of life can impact risk for diabetes.