June 23, 2014
Timme-Laragy submitted a proposal to examine the role of a transcription factor called Nrf2 in healing wounds. Transcription factors are proteins that bind to specific DNA to control the flow of information to RNA. The study will use zebrafish to investigate the function of Nrf2 in aging and determine whether targeted activation of it can accelerate wound healing in aged fish.
“Impaired wound healing in the elderly presents a significant challenge to care-givers, and is a particular concern for individuals who are either bed-bound, are on anti-coagulant drugs, or suffer from diabetes,” she notes.
During the program Timme-Laragy will attend lectures and group discussions on research design, receive training in developing her research interests, and guidance on writing and submitting grants to the NIA. Timme-Laragy will join a group of 50 researchers at the program, which takes place from August 4-8 at the National Institutes of Health Campus in Bethesda, MD.
Timme-Laragy’s research uses the zebrafish model to understand how early life exposure to pollutants, such as PCBs, affects embryonic development, and how this contributes to the development of diseases such as diabetes. “My hope is that attending this program will enable me to expand my research to properly investigate the later-life effects of early life stage chemical exposures, specifically including problems relevant to aging individuals,” says Timme-Laragy.
For more information on the Butler-Williams Scholars Program, click here.