Bio-Epi Seminar Series

  • Date:
    Oct 18 2013
    12:15pm to 01:15pm
    Arnold 120

    Dr. Patrick F. McArdle, Assistant Professor of Epidemiology & Public Health at the University of Maryland School of Medicine will present a lecture as part of the Bio-Epi Seminar Series. Titled "From Buggy to Bedside: CYP2C19 Genotyping and Anti-Platelet Therapy," the lecture examines how pharmacogenetics, or the ability to tailor pharmacological treatments based on one's genome, offers great hope for the future. Response to the anti-platelet agent, Clopidogrel, and CYP2C19 genotype is one of the first viable models for future success.  This talk will trace that story from the beginning through implementation challenges. The initial discovery was a result of genome wide association studies performed in the Old Order Amish population.  The Old Order Amish are a closed founder population living in Lancaster County, PA.  Initial study design and analytic methods for discovery will be explored. Confirmation, dissemination of findings and formalizing guidelines are all precursory to implementation.  The study of translating scientific findings into clinical care (so called "implementation science"), barriers to full adoption and the University of Maryland's experience in this area will be explored.