Denise Scholtens, PhD, Associate Professor in Preventive Medicine-Biostatistics and Neurological Surgery at the Northwestern University Feinberg School of Medicine will deliver a talk titled "HAPO Metabolomics: Preliminary investigations into metabolic networks underlying associations between maternal glucose during pregnancy and newborn adiposity."
Offspring of mothers with pre-existing or gestational diabetes mellitus (GDM) are at risk for higher offspring birth weight and fatness and have an increased risk of metabolic disorders in childhood. These risks likely relate, in part, to fetal over-nutrition in the setting of maternal hyperglycemia and associated variability in maternal fuels. The international, observational Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study, conducted 2000-2006, demonstrated a linear relationship between maternal glucose and offspring birth weight and fatness. This association is likely mediated through fetal glucose-stimulated insulin secretion; however, maternal fuels in addition to glucose also likely contribute. HAPO Metabolomics projects seek to characterize the maternal and fetal metabolic milieus associated with maternal hyperglycemia as well as newborn birth weight and adiposity.
In this presentation, we will discuss preliminary results for 400 HAPO mothers of European ancestry and their offspring using metabolic profiles comprised of conventional clinical metabolites, targeted analyses of amino acids and acylcarnitines, and non-targeted gas chromatography/mass spectrometry (GC/MS) analyses. Data were generated using fasting and 1-hour serum samples from an oral glucose tolerance test in mothers and cord serum in newborns. We will highlight statistical analytic issues and proposed solutions including GC/MS data normalization in this large scale study, metabolic network construction, and identification of local community associations in maternal and newborn networks.
*Food will be provided*
For more information, contact: Deb Osowski at firstname.lastname@example.org or 413-545-4603.