Delivery Breakthrough: Unlocking and Manipulating T-Cells to Advance Immunology
The scanning electron micrograph above shows a human T cell. Until recently, medical researchers had little hope of experimentally manipulating naïve T cells to study their crucial roles in immune function, because they were largely impenetrable. UMass Amherst polymer scientist Gregory Tew and his colleagues including immunologist Lisa Minter have found a way not only to get inside naïve T cells, but to deliver bio-active cargo such as proteins and synthetic molecules across the long-locked cell membrane using new macromolecules coined "PTD mimics". Learn more.
Photo credit: National Institutes of Aging and Infectious Disease