Rapid and Efficient Detection and Identification of Pathogens and Proteins

Primary Inventors: 
Description: 

This technology uses a novel, "chemical nose" approach to the detection and identification of pathogens and proteins. Classes of gold nanoparticle-fluorescent polymer complexes are developed as selective receptors-reporters for pathogen or protein binding. These receptor-reporter constructs function by selective binding to analytes through unique surface interactions between analytes and nanoparticles, producing distinct fluorescence response patterns upon the displacement of the bound fluorescent polymers. These response patterns are quantitatively differentiated by linear discriminant analysis.

Applications: 
  • Rapid detection and identification of pathogens in water samples and in biological fluids
  • Rapid detection and identification of proteins and biomarkers for research, drug discovery and development, and disease diagnosis
Advantages: 
  • Rapid and efficient analyte detection and identification with minimal sample preparation
  • Simple sensor operation and short data processing time
  • Low-cost sensor production
  • Broad sensor tunability via chemical modification of functionalized gold nanoparticles
Licensing Status: 
Available for Licensing or Sponsored Research
Patent Status: 

US Patent 8,003,404 and 8,021,891 issued

Docket: 
UMA 07-43 and UMA 08-03
For More Information: 

Ling X. Shen, Ph.D., M.B.A.
Licensing Officer
Commercial Ventures & Intellectual Property
Phone: 413-545-5276
EMail: lxshen@research.umass.edu