Renewable Surfaces for Capture, Killing and Release of Bacteria

Primary Inventors: 
Description: 

This invention provides economical, renewable surfaces and related methods for selective capture of bacteria in a fluid medium and for killing and/or release of the captured bacteria. The fabrication of these surfaces or surface-treated substrate materials does not require the use of expensive biomolecules and toxic chemicals. The surfaces capture and kill bacteria on contact without leaching any toxic antimicrobial agents. The surfaces can rapidly release captured or killed bacteria via mechanical means, and thus are easily renewable for subsequent round of bacterial capture, killing and release, which makes them ideal for use in on-line bacterial sensor systems. In addition, the surfaces can be engineered to selectively capture bacteria from complex fluid media or selectively capture one bacterial strain over another.

Applications: 
  • Continuous monitoring, on-line sensors for bacteria in fluids
  • Non-leaching antibacterial surfaces, tubing and fittings for life sciences applications
  • Non-leaching antibacterial catheters
  • Whole-cell diagnostic surfaces that selectively capture bacterial targets
Advantages: 
  • Does not require toxic, leached agents, such as ionic silver, for bacterial killing
  • Does not require harsh/toxic chemicals for bacterial removal
  • Does not require multiple processing steps for surface regeneration
  • Can be engineered to selectively capture bacteria in the presence of proteins or to discriminate between different broad bacterial classes
Licensing Status: 
Available for Licensing and/or Sponsored Research
Patent Status: 

Patent process initiated

Docket: 
UMA 13-027
For More Information: 

Ling X. Shen, Ph.D., M.B.A.
Senior Licensing Officer
Commercial Ventures and Intellectual Property
Phone 413-545-5276
E-mail: lxshen@research.umass.edu