A General Method for the Formation of Aryl-Sulfur Bonds
This is a palladium free general method for the formatin of aryl-sulphur bonds from aryl-iodides using catalytic amounts of copper iodide and neocuproine (2,9-dimethylphenanthroline) as the catalyst.
This method replaces the use of expensive palladium based methods of synthesis for complex molecules or drugs, as well as eliminating the need for certain additives.
- Unlike palladium-based complexes, the Cu (I) complex catalyst is extremely inexpensive and easy to prepare
- The Cu (I) complex is air stable, can be stored for long periods of time, and soluble in many organic solvents
- The solvent used is toluene, not the more toxic and polar solvents DMF and pyridine as in prior art.
- The reactions conditions are mild and tolerates various functional groups
- Copper is used in catalytic amounts, instead of stoichiometric amounts
US Patent 7,112,697 issued
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