Cigarette smoking disproportionately affects the health of people in low- and middle-income countries (LMIC). Similar to other LMIC, smoking prevalence is high in Nepal—particularly among people who inject drugs (PWID). Given this burden, Gaurav’s project seeks to evaluate the effects of the 5A (Ask, Advise, Assess, Assist, and Arrange) smoking cessation program among PWID attending opioid substitution therapy (OST) in Kathmandu, Nepal. This project will be carried out in partnership with the Society for Positive Atmosphere and Related Support to HIV and AIDS and Kathmandu Medical College. During Gaurav’s ten-month stay, he will conduct a baseline survey, intervention, and follow-up surveys at two OST sites in Kathmandu Valley. The primary outcomes of this project will include quit rate, quit attempts, quit duration, and changes in smoking frequency. Additionally, he will utilize local health care workers at the OSTs to conduct the group-based counseling for tobacco cessation. Systematically educating this population already vulnerable to various detrimental health outcomes may be beneficial to PWID, their families, and the nation’s health care infrastructure as a whole.