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Workshop Overview |
Protein Data Bank & PDB Codes
Proteopedia.Org Crystallographic Resolution |
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Finding molecular models of interest
Each participant should find a molecule of personal interest. |
Review of Protein Chemistry and Structure.
We'll do this quickly. The links are for participants who are educators. |
Click to see details. |
Evolutionary Conservation: ConSurfDB & ConSurf |
Enolase (4enl; a glycolytic enzyme) evolutionary conservation from ConSurf. Catalytic cleft is at the left. More.. | ||
Effect of mutation on protein function | Genetic consequence | Example |
Function LOST** |
CONSERVED:
mutation LOST from gene pool |
R133C* |
None |
NOT conserved:
mutation remains in gene pool |
E143?* |
* in methyl CpG binding protein 2 (MeCP2),
3c2i:
ASASPKQRRS IIRDRGPMYD DPTLPEGWTR KLKQRKSGRS AGKYDVYLIN PQGKAFRSKV ELIMYFEKVG DTSLDPNDFD FTVTGRGSPS RHHHHHH ^ ^ ** R133C causes Rett syndrome, a severe neurological disorder. Gray: disordered in crystal, absent in model 3c2i. |
FirstGlance in Jmol: Easy Visualization of Any Macromolecule |
Potassium channel (1R3J) showing membrane surface planes (from OPM). See the Resources tab in FirstGlance. |
Contacts: Anti-Alzheimer's drug analog (*) interaction with acetylcholinesterase (Dvir et al./Sussman, 2002). |
Introduction to Structural Bioinformatics and Genomics
Educators: You are welcome to use the slides linked below, or to adapt content from them into your own slides. |
Polyview-3D for Animated Powerpoint Slides and Publication-Quality Images: |
PowerPoint-Ready Animation from Polyview-3D. Click on the image for a larger view and explanation. |
Proteopedia.Org (Part II): Authoring |
Jmol in Scientific Journals: |
Educational Resources |
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Morph of the lactose repressor bending DNA as it recognizes the operon. More.. |
Molecular Modeling (Time Permitting, or Later Private Sessions) |