Global Protein Structure Issues
  1. How are 3D macromolecular structures obtained? Crystallography, NMR, and homology modeling.

  2. What fraction of the human proteome has known tertiary structure? A few percent.

  3. Is Structural Genomics the answer? Not in the next few years.

  4. Intrinsicially unstructured proteins:

by Eric Martz, University of Massachusetts, July 2003