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Intrinsically Disordered Protein
Some proteins are intrinsically unstructured/natively disordered
in order best to support their functions.
- ~10% of proteins are predicted to be fully disordered.
Examples (bound to structured proteins):
1JSU,
1G3J,
1OCT
(Tompa,
2002).
- ~40% of eukaryotic proteins have at least one long (>50 residues)
disordered region.
- A database of disordered proteins (DisProt)
and disordered structure prediction servers
(DisProt,
FoldIndex,
DisEMBL,
GlobProt) are available.
by
Eric Martz, University of Massachusetts, 2003 (last updated 2005).
More:
Proteopedia,
PE.
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