What percentage of the human proteome has known structure?
Answer (homology modeling): ~40% of domains
Solution: Structural Genomics?
This estimate does not take into account redundancy among the ~40,000 human genes. If you know how to estimate that redundancy, please tell me (email@example.com).
by Eric Martz, University of Massachusetts, July 2003 (revised February 2004, September 2005, October 2006, April 2007, May 2012)
Rough estimates in agreement with the 2006 numbers were stated by Kevin Karplus in October, 2006.