[Play Movie #1]
70 seconds, 3.4 megabytes.
Toobers can also be used by teams of students for
hands-on discovery. An
inexpensive kit with instructions for a protein
folding challenge is available from
Toobers for scientific education
are available from 3DMolecularDesigns.com
who also offer more ideas for toobers.
Caveat: the movie clips here intentionally oversimplify some concepts for the sake of brevity. Yes, I know that my "DNA" doesn't have major and minor grooves (adding them would be easy enough), that immunoglobulin domains have more than a few beta strands, and that there are no disulfide bonds holding VH to VL.
Fig. 2 shows the "end" of the antigen model, while Fig. 3 shows
the "side" of the same model. In Fig. 2 is visible a strip
of red tape representing a typical continuous epitope
that could be presented by MHC and recognized by a T lymphocyte.
The continuous epitope is a linear sequence of amino acids.
Unlike the discontinuous epitope recognizable by antibody
(but not by a T lymphocyte), the continuous epitope
is not dependent upon conformation (native vs. denatured).
epitopes: discontinuous vs. linear
and denaturation with heat
[Play Movie #2]
1 min 55 sec, 5.4 megabytes.
paratope of antibody;
alignment of hypervariable regions
[Play Movie #3]
3 min 20 sec, 9.5 megabytes.