The Structural Basis for the Suppression of RNA Silencing by a Plant Viral Protein
Copyright 2005 © by Wayne Decatur. All rights reserved.
RNA silencing is a gene inactivation system in many eukaryotes that relies on tiny RNAs as the targeting molecules. One function of RNA silencing is to act in surveillance against molecular parasites, such as viruses. Double-stranded RNA triggers the RNA silencing pathway and most plant viruses use a double-stranded RNA to replicate their genome. Various plant viruses have developed evasion techniques to circumvent this surveillance sytem. In one such evasion strategy, the plant viral protein p19 suppresses a plants anti-viral RNA silencing response. p19 binds with high affinity double-stranded RNA silencing mediator, called siRNA, and this binding sequesters the siRNA, preventing its participation in later steps of RNA silencing. Structural studies have now revealed how p19 selectively recognizes the double-stranded siRNA.
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I suggest you check out the references below and citations therein if you would like any more information about p19 or the phenomenon of RNA silencing, which is also known as RNA interference or RNAi.
This is a Presentation in Protein Explorer (PiPE) prepared with proteinexplorer.org. Development of Protein Explorer was supported by a grant to Eric Martz from the Division of Undergraduate Education of the US National Science Foundation.