The SH2 domain of phospholipase C gamma-1 (backbone) is bound to a peptide domain from the platelet-derived growth factor receptor (spacefilling) which includes a phosphotyrosine. Although not evident in this image, the center of the receptor peptide is hydrophobic, and the ends, hydrophilic. This interaction activates the phospholipase to cleaves phosphatidyl inositol bisphosphate to yield the second messengers inositol trisphosphate (IP3) and diacyl glycerol (DAG), not shown.

Hydrogens are not resolved in this NMR minimized average structure. This image was created from atomic coordinate file 2PLD.PDB.

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