Further Resources on Protein Secondary Structure
Most biology textbooks have good introductions to protein secondary structure.
An excellent intermediate-level overview of protein structure is
Introduction to Protein Structure by Carl Branden and John
Tooze (1991, Garland Publishing Co., New York).
Kinemages are available for each chapter in this book (you will
need the free viewer
MAGE to view them).
- My nomination for the best treatment of protein secondary
structure on the web is the animated and colorful yet thorough and
quantitative treatment of protein G entitled
Protein Architecture by Will McClure at Carnegie-Mellon
University, Pittsburgh PA. This tutorial uses Chime for animated
3D views of structure.
When you finish the tutorial, you can take McClure's fun 20-question
Protein Architecture Quiz, where you answer by clicking on the molecular
More excellent biochemical resources will be found at McClure's
Molecular Models for Biochemistry at CMU page.
Medical Biochemistry site at the U Kansas Medical Center includes
Chime tutorials on protein secondary structure and domains.
Avoid peak hours for viewing these as they are
o so slo o o o o w to download.
Protein Structure Tutorial by Andrew Coulson, University of
Edinburgh UK. This text tutorial is designed to be used in
conjunction with RasMol. It teaches recognition of the main
elements of protein secondary structure, and the main structural
classes of globular proteins. The tour begins with an examination
of RNAse, continues with two alpha proteins (cytochrome B562 and
myoglobin), two beta proteins (crystallin and retinol-binding
protein), and two alpha/beta proteins (triosephosphate isomerase and
flavodoxin). It ends with an open-ended exploration of a
Structure and Packing of the Alpha Helix, by Duane Sears and Debbie
Richards, University of California, Santa Barbara. A detailed
exploration of the structure of sperm whale oxymyoglobin, emphasizing use
of the RasMol command line.
Structure and Packing of the Beta Pleated Sheet, by Duane Sears,
Tina Leuthard, Jason Gines, and Debbie Richards, University of
California, Santa Barbara. A detailed exploration of the structures
of the plant lectin concanavalin A, and the enzymes carboxypeptidase A and
triose phosphate isomerase, emphasizing use of the RasMol command
Feedback to Eric Martz.