Why Do We Care
about 3D Macromolecular Structure?

  • To understand fundamental biological mechanisms of
    • DNA, RNA
    • enzymes (organic catalysts): anabolic, catabolic
    • hormones, cytokines
    • receptors, signalling cascades, transmembrane pumps
    • photodetectors
    • antibodies
    • structural proteins (collagen, tendons, fingernails/hair)
    • protein motors (muscle, bacterial flagellar motors)
  • Disease: mutation, prions
  • Drug design
From ProteinExplorer.Org