Intrinsically Disordered Protein

Some proteins are intrinsically unstructured/natively disordered in order best to support their functions.

  1. ~10% of proteins are predicted to be fully disordered.
    Examples (bound to structured proteins): 1JSU, 1G3J, 1OCT (Tompa, 2002).

  2. ~40% of eukaryotic proteins have at least one long (>50 residues) disordered region.

  3. A database of disordered proteins (DisProt) and a disordered structure prediction server (DisEMBL) are available.

by Eric Martz, University of Massachusetts, July 2003 (revised February 2004, October 2004, January 2005)

Literature with Excerpts.