Intrinsically Disordered Protein
Some proteins are intrinsically unstructured/natively disordered
in order best to support their functions.
- ~10% of proteins are predicted to be fully disordered.
Examples (bound to structured proteins):
1JSU,
1G3J,
1OCT
(Tompa,
2002).
- ~40% of eukaryotic proteins have at least one long (>50 residues)
disordered region.
- A database of disordered proteins (DisProt)
and a disordered structure prediction server
(DisEMBL) are available.
by
Eric Martz, University of Massachusetts, July 2003 (revised February 2004,
October 2004, January 2005)
Literature with Excerpts.