Protein Explorer Advisories

Some issues have arisen recently that create problems for Protein Explorer users. These problems are not yet addressed within Protein Explorer. Addressing them in a new version of Protein Explorer will take some time. Until further notice, this Advisories page is the only place where solutions are provided.

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  1. Internet Explorer Seven (7) (Windows) does not yet work with Protein Explorer. Although Chime 2.6 SP7 was released in August, 2007, to support Internet Explorer 7, Protein Explorer has not yet been upgraded to use this version of Chime. Firefox is free and is recommended for Protein Explorer. If you are unable to use Firefox or Internet Explorer 6 on your Windows computer, we regret being unable to provide a Protein Explorer that you can use at this time. We do expect to release a Protein Explorer upgrade that supports IE7 later in 2007.

  2. Chime 2.6 SP6 must be used with Internet Explorer Six (6) and Firefox (Windows). Note that SP6 is NOT the latest version of Chime available for download, but it IS available at MDL's Chime download site. If you installed Chime recently, but Protein Explorer says
      Sorry, but either the Chime plugin is not installed in your browser, or it is not sufficiently recent to work with Protein Explorer.
    then most likely you installed SP7. To check the version of Chime installed in your browser:
    • Go to our Chime Test Site.
    • If you don't see the pink ball, you don't have Chime installed in this browser.
    • If you see the pink ball, right-click on it, and then, on the menu that appears, click on About..., and Chime's version is displayed.

  3. If you are using Mac Classic (OS9) with Netscape Communicator 4.8, please continue to use Chime 2.6 SP4, which is the most recent release for Macs.

  4. DNA is not correctly displayed by Protein Explorer in PDB files remediated by the Protein Data Bank. All files obtained from the World Wide Protein Data Bank since August 1, 2007, are remediated. When you type a PDB identification code into the FrontDoor of Protein Explorer, you now get the remediated PDB file. This problem is within MDL Chime, and is not under our control. If you need to explore a molecule containing DNA, here are two solutions:

    • Use FirstGlance in Jmol instead of Protein Explorer. It works much better with the DNA in remediated files. It does noncovalent bonding "contacts" analyses similar to those of Protein Explorer. Although it does not let you make customized molecular views, those can be made easily at publication quality with Polyview-3D.

    • If your DNA-containing PDB file was published before August 1, 2007, use the unremediated PDB file.

Proceed to the Protein Explorer FrontDoor