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In October, 2005, the first empirical structure for a B-form to Z-form transition in a DNA double helix was reported by Ha, Lowenhaupt, Rich, Kim & Kim. The surprise was that only a single base pair is broken, with these two bases extruded. Rotate by dragging on the molecule. Zoom by holding down the Shift key and dragging up or down on the molecule. Made with MolSlides.Org

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DNA B-Form to Z-Form Transition Two bases are extruded at the transition. The transition structure comes from a crystal structure (2ACJ) stabilized with a Z-form-binding protein. The B- and Z- forms have been extended in the model shown here, kindly provided by Kyeong Kyu Kim (Nature 437:1183, 2005) Made with MolSlides.Org

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DNA B-Form to Z-Form Transition Two bases are extruded at the transition. This is the crystallographic result, showing three protein domains bound to the less stable Z-Form, stabilizing it. Made with MolSlides.Org

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DNA B-Form to Z-Form Transition Backbone view, with extruded bases at the transition. Made with MolSlides.Org

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DNA B-Form/B-Form to Z-Form/Z-Form Transition Strands distinguished, also the two extruded bases at the transition. Made with MolSlides.Org

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