Volunteer Opportunities


The Muscle Biology and Imaging Lab at the University of Massachusetts Amherst regularly seeks individuals to participate in research studies. View current volunteer opportunities.

Awards and Honors


View awards and honors received by MBIL graduate students.

MBIL Alumni


Doctoral students from the Muscle Biology and Imaging lab have gone onto prestigious positions at top research institutions across the country. View our alumni.

Department and College


Robert Hyldahl

Graduate Research Assistant
(413) 545-6072
rhyldahl@kin.umass.edu

I am a doctoral student in the Muscle Biology and Imaging lab. I received my master’s degree from UMass Amherst and my undergraduate degree from the University of Utah. My research interest is in the molecular response of muscle tissue to various stimuli, particularly disuse and eccentric contraction-induced damage.

Current projects include:

1. The development of a novel in vitro model of muscle atrophy and the application of that model to understand the role of metallothionein proteins in the atrophy response.

2. A microarray analysis of muscle biopsies taken from subjects following a damaging eccentric exercise.

During my time at UMass, I have also worked on projects to investigate the effects of an ibuprofen topical gel on soreness following eccentric exercise and a study designed to determine the effects of statin drugs on muscle performance.

In addition to my research, I am an instructor in the department of kinesiology where I teach the junior year writing course. This course is designed as a professional writing course wherein students learn to write a resume, cover letter and personal statement and are also taught technical science writing skills including a literature review and grant proposal. Aside from my work as a doctoral student, I enjoy spending time with my beautiful wife Rowena and 2 year-old-son Sid. We enjoy cycling, skiing, climbing and simply being outdoors.

Publications

Hyldahl RD, Keadle J, Rouzier PA, Pearl D, Clarkson PM. Effects of Ibuprofen Topical Gel on Muscle Soreness. Med Sci Sports Exerc, Mar 2010; 42(3): 614-21.

Hyldahl RD, O’Fallon KS, Schwartz LM, Clarkson PM. Knockdown of metallothionein 1 and 2 does not affect atrophy or oxidant activity in a novel in vitro model. J Appl Physiol, Nov 2010; 109: 1515-1523.

Hyldahl RD, Xin L, Moeckel-Cole S, Hubal MJ, Chipkin S, Clarkson PM.  Activation of Nuclear Factor-kB in Human Skeletal Muscle Residing Pericytes Following Eccentric Exercise-Induced Damage. FASEB, In Review. 

 

Publications Resulting From Presentation at a Conference

Hyldahl, RD, Xin L, Hubal M, Moekel-Cole S, Chipkin S, Clarkson PM. Activation of NF-kB in Pericytes of Human Skeletal Muscle Following Eccentric Exercise-Induced Damage. Med Sci Sports Exerc. 42(10):96, October 2010.

Conference: Integrative Physiology of Exercise, Miami, September 2010.

 Hyldahl RD, Ramakrishnan S, Xin L, Riska, KL, Chipkin S, Murray MA, Greger V, Prabhakar P, Shaver K, Clarkson PM. Two Botanical Supplements with Antioxidant and Anti-inflammatory Properties Protect Against Eccentric Exercise-Induced Strength Loss. Med Sci Sports Exerc. 42(5):385, May 2010.

Conference: American College of Sports Medicine, Baltimore, May 2010.

 Xin L, Ramakrishnan S, Hyldahl RD, Riska, KL, Chipkin S, Murray MA, Greger V, Prabhakar P, Shaver K, Clarkson PM. The Effects of Two Botanical Supplements on Gene Expression Following Eccentric Exercise. Med Sci Sports Exerc. 42(5):383-384, May 2010.

Conference: American College of Sports Medicine, Baltimore, May 2010.

 Riska KL, Ramakrishnan S, Xin L, Hyldahl RD, Riska, KL, Chipkin S, Murray MA, Greger V, Prabhakar P, Shaver K, Clarkson PM. Gene Expression Profiling of Skeletal Muscle After Eccentric Exercise. Med Sci Sports Exerc. 42(5):8, May 2010.

Conference: American College of Sports Medicine, Baltimore, May 2010.

 Hyldahl RD, Sewright KA, Schwartz LM, Clarkson PM. Growth Factor Withdrawal: A Novel Approach to in vitro Muscle Atrophy. Med Sci Sports Exerc. 41(5):79, May 2009.

Conference: American College of Sports Medicine, Seattle, May 2009.

 Hyldahl RD, Sewright KA, Schwartz LM, Clarkson PM. A Novel Model of Muscle Atrophy. Med Sci Sports Exerc. 40(5) Supplement: S241-S242, May 2008.

Conference: American College of Sports Medicine, Indianapolis, May 2008.

 Hyldahl RD and PM Clarkson. The Effects of CoQ9 and CoQ10 Treatment on Muscle Cell Viability. Med Sci Sports Exerc. 39(5) Supplement: S221, May 2007.

Conference: American College of Sports Medicine, New Orleans, May 2007.

 

Presentations

1. Two Botanical Supplements with Antioxidant and Anti-inflammatory Properties Protect Against Eccentric Exercise-Induced Strength Loss, New England Chapter of ACSM Annual Meeting, Providence, RI. 11/2009

2. Growth Factor Withdrawal: A Novel Approach to in vitro Muscle Atrophy, American College of Sports Medicine Annual Meeting, Seattle, WA. 05/2009

3. &ldquGrowth Factor Reduction; a Novel Model of Muscle Atrophy, School of Public Health and Health Sciences Research Day, 03/2009

4. Growth Factor Withdrawal Produces the Morphological and Biochemical Changes Associated with Disuse Atrophy, New England Chapter of ACSM Annual Meeting, Providence, RI. 11/2008

5. A Novel Model of Muscle Atrophy, American College of Sports Medicine Annual Meeting, Indianapolis, IN. 05/2008

6. The Effects of CoQ9 and CoQ10 Treatment on Muscle Cell Viability, American College of Sports Medicine Annual Meeting, 06/2007

7. The Effects of CoQ9 and CoQ10 Treatment on Muscle Cell Viability, School of Public Health and Health Sciences Research Day, 04/2007

Grants/Awards

University of Massachusetts Amherst Graduate Student Fellowship Award (Academic Year 2010-2011)

ACSM Foundation NASA Research Initiative Grant: The Effect of Metallothionein Knockdown on Muscle Atrophy and Oxidative Stress (7/2009 - 7/2010)

ASCM Foundation NASA Research Initiative Grant SENP1, a possible novel regulator of muscle atrophy (7/2007 7/2008)

UMass Space Grant Fellowship: A Novel in vitro Model of Muscle atrophy (2008)

Mark Connelly Memorial Scholarship, New England Chapter of the American College of Sports Medicine (2007)

Muscle Response Research

Activation of NF-kb in cells outside the myofiber boundary, 3h following eccentric exercise (ECC). A. Confocal images of triple stained 10µm sections from a representative ECC sample for dystrophin (dys=blue), the p-65 subunit of NF-kb (p65=green) and nuclei (topro3=red). White square in merged image denotes the boundaries of the inset image. Scale bar in top 3 images and merged image = 20µm; scale bar in inset image = 10µm. Read the abstract.

Resistance Exercise and Cancer

Dr. Clarkson's research on resistance exercise during breast cancer treatment is featured in Medical Hypothesis, a journal of theoretical papers in the biomedical sciences. Read the abstract.

Rhabdomyolysis

Rhabdomyolysis is a serious, potentially life-threatening condition that can develop unexpectedly under supervised conditions. Dr. Clarkson's 2009 paper in The Journal of Strength and Conditioning Research examines a case of rhabdomyolysis in a healthy, fit 18-year-old placekicker following a supervised practice session led by the team's strength and conditioning coach. Following eight days of hospitalization with intravenous fluids, the patient recovered without complications. View the full abstract.