University of Massachusetts Amherst

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UMass Mass Spectrometry

The Mass Spectrometry Center at UMass Amherst maintains a suite of state-of-the-art analytical mass spectrometry equipment, providing analytical services and expertise in mass spectrometry to researchers across a broad range of disciplines at UMass-Amherst and neighboring academic institutions, as well as in collaboration with industrial partners. Mass spectrometry services facilitate a range of research in the life sciences, as well as in chemistry and polymer science.  Examples include characterization of intact proteins, determining sites of chemical or post-translational modification using top-down and bottom-up approaches, metabolite and other natural product determination and quantitation, as well as analysis of novel synthetic organic/inorganic compounds and polymeric materials. Other research groups who make use of the Center instrumentation are involved in investigation of protein dynamics by hydrogen/deuterium exchange, understanding and tailoring enzyme mechanisms, and also MS method development and fundamental studies in protein/protein and protein/ligand interaction.

Instrumentation in the Mass Spectrometry Center is incorporated into various academic courses at the undergraduate and graduate level, including interdisciplinary programs such as the Chemistry-Biology Interface Program, Institute for Cellular Engineering. Recent funding from the Commonwealth of Massachusetts to create the Institute for Applied Life Sciences has enabled substantial improvements in the capabilities of the Center, particularly with regard to the burgeoning field of biological mass spectrometry.

Instrumentation in the Center encompasses a broad range of analytical capabilities from small molecule analysis to large biopolymers, including GC-MS, HPLC-MS, UPLC and nanoLC chromatography systems.  For more details, see Instrumentation.