UMass Amherst

Vincent M. Rotello

Professor, Dept. of Chemistry
1317 Lederle GRT, University of Massachusetts
Amherst, MA 01003-9292
(413) 545-2058
rotello@chem.umass.edu
http://www.umass.edu/rotellogroup

Biological and Materials Applications of Nanoparticles

Our research program focuses on achieving a fundamental understanding of supramolecular chemistry and the application of this understanding to issues in biological and materials science. The focus on molecular recognition provides a unifying theme for these two main areas of our highly multidisciplinary research program.

Research Interest Potential Application
Nanoparticle-Based Therapeutics Gene Delivery, Drug Delivery, Hyperthermic Cancer Therapy, Sensors And Diagnostics
Bionanocomposite Fabrication Sensors, Biosystems

Honors and Awards

  • Alfred P. Sloan Fellowship, 1997
  • Camille and Henry Dreyfus Teacher-Scholar Award, 1997
  • National Science Foundation CAREER Award, 1997
  • Cottrell Scholar Award, Research Corporation, 1996
  • University Lilly Teaching Fellowship Award, 1996

Publications

  1. Drechsler, U.; Fischer, N. O.; Frankamp, B. L.; Rotello, V. M. “Highly Efficient Biocatalysts via Covalent Immobilization of Candida rugosa Lipase on Ethylene Glycol Modified Gold-Silica Nanocomposites” Adv. Mat., 2004, 16, 271-274.
  2. Hong, R.; Fischer, N. O.; Verma, A.; Goodman, C. M.; Emrick, T. S.; Rotello, V. M. “Control of Protein Structure and Function through Surface Recognition by Tailored Nanoparticle Scaffolds” J. Am. Chem. Soc., 2004, 126, 739-743.
  3. Frankamp, B. L.; Boal,, A. K.; Rotello, V. M. “Controlled Interparticle Spacing Through Self-Assembly Of Au Nanoparticles And Poly(Amidoamine) Dendrimers” J. Am. Chem. Soc., 2002,124, 15146-15147.
  4. Frankamp, B. L.; Uzun, O.; Ilhan, F.; Boal, A. K.; Rotello, V. M. "Recognition-mediated assembly of nanoparticles into micellar structures with diblock copolymers" J. Am. Chem. Soc. 2002, 124, 892-893.
  5. Boal, A. K.; Ilhan, F.; DeRouchey, J. E.; Thurn-Albrecht, T.; Russell, T. P.; Rotello, V. M. "Self-assembly of nanoparticles into structured spherical and network aggregates" Nature 2000, 404, 746-748.