Michael J. Knapp
Assistant Professor, Dept. of Chemistry
512 LGRT, University of Massachusetts
Amherst, MA 01003-9292
(413) 545-4001
mknapp@chem.umass.edu
http://www.umass.edu/knappchem
Enzymology and Biosensors
Our research program focuses on enzymology, with efforts to understand enzyme chemistry, inter-protein recognition, and the mechanisms of biological signaling. Nanomaterials are being explored as inhibitors, activators, and stabilizers of enzyme function. This research has direct impact in the disparate areas of health and homeland security.
| Research Interest | Potential Application |
|---|---|
| Controlling the function of enzymes involved in angiogenesis | Therapeutics for stroke and cancer |
| Synthesis of bio-nanocomposite materials | Enzyme-based sensors for threat detection |
Publications
- Knapp, M. J.; Klinman, J. P. "Kinetic studies of oxygen reactivity in soybean lipoxygenase-1," Biochemistry 2003, 42, 11466-11475.
- Knapp, M. J.; Rickert, K.; Klinman, J. P. "Temperature-dependent isotope effects in soybean lipoxygenase-1: Correlating hydrogen tunneling with protein dynamics," J. Am. Chem. Soc. 2002, 124, 3865-3874.
- Francisco, W. A.; Knapp, M. J.; Blackburn, N. J.; Klinman, J. P. "Hydrogen tunneling in peptidylglycine alpha-hydroxylating monooxygenase," J. Am. Chem. Soc. 2002, 124, 8194-8195.
- Knapp, M. J.; Seebeck, F. P.; Klinman, J. P. "Steric control of oxygenation regiochemistry in soybean lipoxygenase-1," J. Am. Chem. Soc. 2001, 123, 2931-2932.
- Knapp, M. J.; Krzystek, J.; Brunel, L. C.; Hendrickson, D. N. "High-frequency EPR study of the ferrous ion in the reduced rubredoxin model [Fe(SPh)4]2-," Inorg. Chem. 2000, 39, 281-288.
