Craig T. Martin
Professor, Dept. of Chemistry
701A Lederle GRT, University of Massachusetts
Amherst, MA 01003-5110
(413) 545-3299
CMartin@chem.umass.edu
http://www.chem.umass.edu/~cmartin
Biological Applications of Nanoparticles, Nucleic Acids
Applications of nucleic acids, both chemically and biochemically synthesized, to generate novel molecules and interactions. The inherent self-templating available in nucleic acids complements well the ability of nanoparticles to be imprinted, setting up a synergy that may be exploited for the design of both structure and function. This work complements our group's primary focus on the enzymology of transcription by T7 RNA polymerase, an enzyme widely used in the biotechnology industry.
| Research Interest | Potential Application |
|---|---|
| DNA-nanoparticle sequence-specific recognition | Gene-targeted therapeutics |
| Nanoparticles for transfection | Improved transfection methodologies |
| Nucleic acid - quantum dot interactions | Gene diagnostics |
| Novel nucleic acid structures and dynamics | Patterned and functional materials |
Honors and Awards
- Member National Science Foundation Panel: Biochemistry of Gene Expression, 1997-2002
- Executive Committee: Chemistry-Biology Interface Training Program, Univ. of Mass.
- National Research Service Award, National Institutes of General Medical Sciences, 1986-88
- Elected to Sigma Xi, 1984
- William Barton Jones Fellowship
Publications
- "Gold Nanoparticles with Biological Activity: Disruption of Transcription via Electrostatic Attraction," Catherine M. McIntosh, Edward A. Esposito, III, Andrew K. Boal, Joseph M. Simard, Craig T. Martin, & Vincent M. Rotello, J. Am. Chem. Soc., 123, 7626-7629, 2001
- Evaluation of fluorescence spectroscopy methods for mapping melted regions of DNA along the transcription pathway," Craig T. Martin, Andrea Újvári, & Cuihua Liu, Methods in Enzymology, S. Adhya & S. Garges, eds., (invited), 371, 13-33, 2003.
