Engineered Models and Mechanisms in Cancer (EM²C)
Members of the Engineering Models and Mechanisms in Cancer (EM²C) research theme have broad expertise with engineering in vitro models to mimic the complexity of tumors and identification of novel therapeutic targets using primary human tissues. Epidemiology is also a strength among the researchers in EM²C providing insights into risk factors and potential targets. This work is complemented by investigations of the molecular basis for variation among individuals using primary cultures of cells and tissues. Although most cancers have shown a steady decline since the 1930s, incidence of breast cancer has increased. Therefore, investigators within the Theme have developed coordinated resources to study mechanisms responsible for the prevalence of breast cancer. This model is being extended to other cancers. The investigators in EM²C use a range of spontaneous and transplantable tumor models in rodents as well as primary human tissues and conditionally immortalized breast epithelial cell cultures with which to validate pathways and drug targets.