We strive to bridge individual strengths of diverse disciplines including nanoparticle-based drug delivery, supramolecular chemistry, glycan engineering, molecular imaging, mathematical modeling and immunology to develop tools and platform technologies for addressing fundamental and translational questions in human diseases, with a goal of developing paradigm shifting immunotherapy strategies.
Dysregulated immune system activation is at the root of several diseases: overactivation can lead to autoimmunity and underactivation can lead to immunodeficiency, compromise resistance to infections and allow for the development of malignancy. Our group works at the interface of engineering and immunobiology to develop innovative technologies for achieving the precise level of immune activation to treat diseases and improve human health. Specific research areas include:
1. IMMUNOENGINEERING: Most of our understanding of immune system interactions in diseases is still limited by the lack of proper tools and techniques. We develop immunoengineering platforms to understand and quantitatively study the interactions between different components of the immune system in health and disease.
2. IMMUNOTHERAPEUTICS: To perturb the interactions between different immune cells at a spatial and temporal scale, and efficiently modulate the immune response, we engineer biologically-inspired immunotherapeutics by utilizing high throughput computational platform technology.
3. IMMUNOTHERANOSTICS: Real-time monitoring of immunotherapy efficacy is an unmet need in clinics. We are developing immuno-theranostic (therapeutic + diagnostic) platform technology that can enable spatiotemporal delivery of an immunotherapy drug and drug function-activatable imaging agent. This technology can not only allow direct and real-time visualization of immunotherapy effect thereby studying heterogeneity in immunotherapy response but can also be utilized to probe interesting biological questions by real-time monitoring of cellular level immune responses.
B. Tech. Chemical Technology, Institute of Chemical Technology, India, 2003
Ph.D. Chemistry, University of Cincinnati, 2011
Postdoctoral Fellowship, Brigham and Women’s Hospital, Harvard Medical school, 2015
Instructor in Medicine, Harvard Medical School, 2017
Associate Bioengineer, Brigham and Women’s Hospital, 2017