The University of Massachusetts Amherst

Please select the first letter of the last name you are looking for.

Agnès Lacreuse

Associate Professor

Our lab studies neurocognitive aging in nonhuman primate models, in the context of typical and pathological aging as well as menopause. 

Current Research
The marmoset is a small nonhuman primate that is increasingly used in neuroscience research due to its close resemblance to humans in many aspects of physiology, brain organization and behavior. Due to a short lifespan of about 12 years, the marmoset is uniquely suited for aging studies.  Three main projects focusing on marmoset neurocognitive aging are ongoing (1) A longitudinal study seeks to identify the biological correlates of sex differences in cognitive and brain aging, using behavioral, physiological, neuroimaging and neurohistological techniques; (2) In a second project, we are developing a marmoset model for menopausal symptoms in order to understand potential interactions between cognitive deficits, sleep disturbances and thermoregulation impairments that are associated with estrogen loss; (3) Recent studies examine the aged marmoset as a model for preclinical Alzheimer's disease, in order to identify behavioral predictors of neuropathology.       

Academic Background

  • PhD Université Paul Sabatier, Toulouse, France,1994
  • Postdoctoral Training: University of Georgia, 1995; Emory University, 1997
  • Postdoctoral Training: Yerkes Natl Primate Res Ctr, Emory University, 1997-2002
  • Res Assistant Professor, Yerkes Natl Primate Res Ctr, Emory University 2002-2006
  • Assistant Professor, University of Massachusetts, 2006-2012
  • Associate Professor, University of Massachusetts, 2012-present
LaClair, MG, Febo, M., Nephew, B., Gervais, N.J, Poirier, G., Workman, K.P., Chumachenko, S., Payne, L., Moore, M.C., King, J.A. & Lacreuse, A. (2019). Sex differences in cognitive flexibility and resting brain networks in middle-aged marmosets. eNEURO.
Gervais, N.J., Remage-Healey, L., Starrett, J.R., Pollak, D. J., Mong, J.A. & Lacreuse, A. Adverse effects of aromatase inhibition on the brain and behavior in a nonhuman primate (2019). Journal of Neuroscience, 39, 918-928.
Workman, K., Carlotto, A. Healey, B. & Lacreuse, A. (2019). One year change in cognitive function and fine motor function in aging marmosets. American Journal of Primatology, 81(2), e22924.
Lacreuse, A., Moore, C.M., LaClair, M., Payne, L. & King, J.A. (2018). Glutamate/glutamine concentration in the prefrontal cortex predicts reversal learning performance in the marmoset. Behavioural Brain Research, 346, 11-15.
Gervais, N. J., Mong, J.A. & Lacreuse, A. (2017). Ovarian hormones, sleep and cognition across the lifespan in females: an integrated perspective. Frontiers in Neuroendocrinology, 47, 134-153 (invited)
Gervais, N., Viechweg, S. Mong, J. A. & Lacreuse, A. (2016). The middle-aged ovariectomized marmoset (Callithrix jacchus) as a model for menopausal symptoms: preliminary evidence. Neuroscience, 337, 1-8
LaClair, MG. & Lacreuse, A. (2016). Reversal learning in gonadectomized marmosets with and without hormone replacement: Are males more sensitive to punishment? Animal Cognition, 19, 619-630.
Lacreuse, A., Mong, J.A. & Hara, Y. (2015). Neurocognitive effects of estrogens across the adult lifespan in nonhuman primates: state of knowledge and new perspectives. Hormones and Behavior (invited review), 74, 157-166.
Contact Info

Department of Psychological and Brain Sciences
Tobin Hall 531
135 Hicks Way
Amherst, MA 01003

(413) 545-2183