The University of Massachusetts Amherst

Mechano-Regulation of Bone Metastatic Cancer: Linking Cell Strain to Cell Function

The Challenge

Because of daily activities such as walking and running, the skeleton features highly dynamic mechanical signals, and these signals regulate all cellular processes within bone.

The Innovation/Technology

The Impact

However, when cancers such as breast spread to the skeleton, their response to this mechanical environment is unknown, but could reveal a suite of novel therapeutic targets.

The Solution

The Lynch and Modarres labs are creating a multi-scale, multi-physics simulation of the mechanical signals within a 3D bone-mimicking scaffold used to study bone metastatic breast cancer cell mechanobiology.

 
Contact Info

Maureen Lynch
Mechanical & Industrial Engineering
LSL N575

(413) 545-6689
maureenlynch@umass.edu