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Applied systems biology strives to understand cellular metabolism and its regulation in order to design superior cellular bioprocesses to fuel applications in pharmaceutical supply, drug delivery, and bioremediation. Research areas include high throughput metabolite analysis, exploration of genetically uncharacterized cell systems, creation of quantitative genomic and metabolic models, and novel microarray analysis.
By enabling researchers to deliver specific cells to targeted body regions, cellular transport systems play a vital role in tissue repair and replacement. Research encompasses stem cell biology, strategies to increase oxygen supply to polymer-encapsulated cells, and promotion of cell-material interactions using nano-patterned surfaces to direct protein adsorption.
As major intracellular functional players, proteins form the core of disease and cure. Protein engineering provides the tools to change molecular properties, and thus cellular behavior, at the most fundamental molecular level. Protein engineering strives to generate proteins with novel structures and functions that can ultimately be integrated into an engineered cell to provide new properties and enzymatic activities. Leading ICE researchers study the proteins responsible for specific aspects of cell death, which could lead to better treatments for cancer, heart attack, stroke, and other diseases.