UMass Amherst
University of Massachusetts Amherst

Institute for Cellular Engineering

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Janice C. Telfer
Assistant Professor, Veterinary and Animal Sciences
Associate Director Institute of Cellular Engineering University of Massachusetts
Amherst, MA 01003
(413) 545-5564
telfer@vasci.umass.edu
http://www.umass.edu/vasci/faculty/telfer/telfer.html


Long-term Reconstituting Hematopoietic Stem Cells

Lab seeks to expand LTR-HSC in vitro while preserving their self-renewal capacity to fully exploit the limited number of these rare cells for effective treatments for a plethora of diseases affecting the hematopoietic system. Lab investigates the potential of mutant Runx transcription factors to disregulate the normal checks on hematopoietic stem cell expansion.

 

Research Interest

Potential Application

Expansion of hematopoietic stem cells in culture

Increased bone marrow transplant success

How material properties impact function of a variety of cell types, including stem cells (w/ Bhatia and Roberts)

Improved viability of stem cells for clinical applications

How mechanical signals from the matrix can be used to direct stem cell development and response  (w/ Roberts)

Expression and differentiation of stem cells

 

 

University of Massachusetts
Institute for Cellular Engineering
686 North Pleasant Street
159 Goessmann Laboratory
Amherst, MA 01003