Long-term Reconstituting Hematopoietic Stem Cells
Lab seeks to expand LTR-HSC in vitro while preserving their self-renewal capacity to fully exploit the limited number of these rare cells for effective treatments for a plethora of diseases affecting the hematopoietic system. Lab investigates the potential of mutant Runx transcription factors to disregulate the normal checks on hematopoietic stem cell expansion.
Research Interest
Potential Application
Expansion of hematopoietic stem cells in culture
Increased bone marrow transplant success
How material properties impact function of a variety of cell types, including stem cells (w/ Bhatia and Roberts)
Improved viability of stem cells for clinical applications
How mechanical signals from the matrix can be used to direct stem cell development and response (w/ Roberts)
Expression and differentiation of stem cells
University of Massachusetts
Institute for Cellular Engineering
686 North Pleasant Street
159 Goessmann Laboratory
Amherst, MA 01003
