UMass Amherst
University of Massachusetts Amherst

Institute for Cellular Engineering

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David Kulp
Assistant Professor, Computer Science
University of Massachusetts
Amherst, MA 01003
(413) 545-2032
dkulp@cs.umass.edu
http://cbl.cs.umass.edu

Biological Computation
My current research interests are primarily resequencing by microarray hybridization and inferring regulatory networks using quantitative trait loci (QTL).  More specifically, my research is composed of both technology development and the analysis of gene regulation.  On the technology side, I am investigating alternative microarray design strategies for improved discrimination of single nucleotide polymorphisms.  I am applying this microarray technology to identify allelic differences within strains of various organisms from mice to the Dengue virus.  On the gene regulation side, I am developing new graphical models for the inference of regulatory relationships among genes and genetic markers and I am assessing the nature of genetic variation on the expression of alternatively spliced isoforms.  I also work with colleagues on genome annotation projects, most notably the genomes of the microbes "Geobacter".

 

Research Interest

Potential Application

Bioinformatics

Understanding of structure function relationships

Microarrays

Discovery of gene function

 

 

 

 

University of Massachusetts
Institute for Cellular Engineering
686 North Pleasant Street
159 Goessmann Laboratory
Amherst, MA 01003