UMass Amherst
University of Massachusetts Amherst

Institute for Cellular Engineering

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Daniel N. Hebert
Professor, Biochemistry and Molecular Biology
University of Massachusetts
Amherst, MA 01003
(413) 545-0079
dhebert@biochem.umass.edu
http://www.biochem.umass.edu/hebert/


Protein maturation and quality control in the mammalian secretory pathway, and understanding the viral life cycle.

My lab is interested in understanding how proteins mature in live mammalian cells. These processes include protein folding, modification, assembly, and trafficking. We are also interested in how the cells monitor the fidelity of protein maturation through a quality control process that sorts defective proteins for degradation, as a large number of human diseases are rooted in maturation defects. Viruses exploit these maturation and trafficking processes for their own propagation. Another focus of the lab is exploring how mammalian viruses usurp these processes during their own viral life cycle.

 

Research Interest

Potential Application

Nonenvelope virus release

Oncolytic targeting of cancer cells

Nonenvelope virus delivery and penetration

Use of viruses for gene therapy, or as gene delivery vehicles

Protein maturation and the role of chaperones

Engineering of cells that are able to efficiently express higher levels of native proteins

Protein quality control and degradation

Correction of protein misfolding disease

University of Massachusetts
Institute for Cellular Engineering
686 North Pleasant Street
159 Goessmann Laboratory
Amherst, MA 01003