Protein maturation and quality control in the mammalian secretory pathway, and understanding the viral life cycle.
My lab is interested in understanding how proteins mature in live mammalian cells. These processes include protein folding, modification, assembly, and trafficking. We are also interested in how the cells monitor the fidelity of protein maturation through a quality control process that sorts defective proteins for degradation, as a large number of human diseases are rooted in maturation defects. Viruses exploit these maturation and trafficking processes for their own propagation. Another focus of the lab is exploring how mammalian viruses usurp these processes during their own viral life cycle.
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