UMass Amherst
University of Massachusetts Amherst

Institute for Cellular Engineering

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Scott C. Garman

Associate Professor, Biochemistry and Molecular Biology
University of Massachusetts
Amherst, MA 01003
(413) 577-4488
garman@biochem.umass.edu
http://www.biochem.umass.edu/faculty/scott-c-garman

Structural Biology of Glycoproteins in Human Disease
Research in our lab focuses on structural biology of glycoproteins, particularly those implicated in human disease.  For instance, deficiencies in lysosomal enzymes result in the accumulation of their substrates, which eventually leads to the symptoms of lysosomal storage diseases (a family containing over 40 members including Gaucher, Tay-Sachs, and Fabry diseases). We have determined the x-ray crystallographic structures of two lysosomal glycosidases, α-N-acetylgalactosaminidase (α-NAGAL) and α-galactosidase (α-GAL), as well as complexes with their catalytic products. The structures revealed the locations of the hundreds of individual point mutations leading to Schindler and Fabry diseases.

 

Research Interest

Potential Application

Lysosomal storage diseases

Therapeutic strategies for 40 members including Gaucher, Tay-Sachs, and Fabry diseases

Malarial surface proteins

Protection against malaria infection

Antibody-receptor interactions

Therapeutic strategies for allergic symptoms

 

 

University of Massachusetts
Institute for Cellular Engineering
686 North Pleasant Street
159 Goessmann Laboratory
Amherst, MA 01003