UMass Amherst
University of Massachusetts Amherst

Institute for Cellular Engineering

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Neil St. John Forbes

Associate Professor, Chemical Engineering
University of Massachusetts
Amherst, MA 01003
(413) 577-0132
forbes@ecs.umass.edu
http://www.ecs.umass.edu/che/forbes/

Tumor Therapeutic and Metabolic Engineering Lab
Application of chemical engineering principles to the study of tumor formation and treatment is fertile new ground for research and is necessary for the advancement of cancer therapy. Standard cancer therapies often fail because of spatial heterogeneity of nutrients, wastes, and therapeutics. Transport barriers prevent therapeutic agents from reaching effective concentrations throughout tumors. In my laboratory we characterize and utilize tumor heterogeneity to develop novel cancer therapies that overcome the limitations of current cancer therapies. Unique three-dimensional tumor models are designed to mimic the metabolic variations observed in tumors in vivo. The metabolic profiles of the tumor models, both in vitro and in vivo, are characterized using fluorescence microscopy, nuclear magnetic resonance spectroscopy and metabolic flux analysis.

 

Research Interest

Potential Application

Targeted Bacteriolytic Therapy

Target therapeutics to quiescent tumor regions, imaging

Localized Quantification of Tumor Metabolism

Model cancer cell proliferation, identify targets to inhibit tumor metabolism and proliferation

Bacterial Migration and Segregation in Solid Tumors

Drug delivery

University of Massachusetts
Institute for Cellular Engineering
686 North Pleasant Street
159 Goessmann Laboratory
Amherst, MA 01003