Provides transgenic, gene targeting, and other services to the research community. The core performs microinjections of DNA into fertilized embryos to generate transgenic mice. Uses cutting-edge technologies, including CRISPR/Cas9 genome editing, to generate gene knock-out or knock-in mice or other animal models. In addition, provides mouse surgery service and training, such as patient-derived xenograft (PDX), tail vein injection, and catheterization. The core is able to customize services as requested to support development of animal models of human diseases in a timely and cost-efficient manner.