Hang Xiao
Assistant Professor, Honors Program Director
Cancer preventive dietary components, diet-based strategy for cancer prevention, enhancement of biological activity of dietary components by combination regimen, food processing and nanotechnology.
Office: Room 338, Chenoweth Laboratory
Off. Tel.: (413) 545-2281
Email: hangxiao@foodsci.umass.edu
Curriculum Vitae |
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Publications (since 2006)
• Peiju Qiu, Ping Dong, Huashi Guan, Shiming Li, Chi-Tang Ho, Min-Hsiung Pan, David Julian McClements and Hang Xiao. (2010) The p53, Bax and p21 dependent inhibition of colon cancer cell growth by 5-hydroxy polymethoxyflavones. (Submitted).
• Guodong Zhang, Shanshan Guo, Peiju Qiu, Feng Li, Viriya Nitteranon, Hang Xiao, Kirk L Parkin . (2010) Organoselenium Compounds Modulate Extracellular Redox through Induction of Extracellular Cysteine and Cell Surface Thioredoxin Reductase. (submitted).
• C.-S. Lai, M.-L. Tsai, A.-C. Cheng, S. Li, C.-Y. Lo, Y. Wang, H. Xiao, C.-T. Ho, Y.-J. Wang, M.-H. Pan (2010) Chemoprevention of colonic tumorigenesis by dietary hydroxylated polymethoxyflavones in azoxymethane-treated mice. (Submitted)
• Yan Li, Min Hu, Yumin Du, Hang Xiao, David Julian McClements. (2010) Control of Lipase Digestibility of Emulsified Lipids by Encapsulation within Calcium Alginate Beads, Food Hydrocolloids – (Revisions submitted).
• Yan Li, Min Hu, Hang Xiao, Yumin Du, Eric Andrew Decker and David Julian McClements (2010) Controlling the functional performance of emulsion-based delivery systems using multi-component biopolymer coatings, Eur J Pharm Biopharm. (in press).
• Qiu, P.; Dong, P.; Guan, H.; Li, S.; Ho, C.T.; Pan, M.H.; McClements, D.J. and Xiao, H. (2010) Inhibitory effects of 5-hydroxyl polymethoxyflavones on colon cancer cells. Molecular Nutrition and Food Research. (in press).
• Lu, G.; Xiao, H.; Li, G.; Chen, Y.K.; Hao, H.; Loy, S.; and Yang, C.S. (2010) A g-Tocopherol-rich mixture of tocopherols inhibits chemically-induced lung tumorigenesis in A/J mice and xenograft tumor growth. Carcinogenesis. 31(4):687-94.
• Li, G.; Chen, Y.K.; Hou, H.; Xiao, H.; Jin, H.; Lu, G.; Lee, M.J.; Liu, B.; and Yang, C.S. (2010) Cancer Inhibitory and Pro-oxidative Activities of (-)-Epigallocatechin-3-gallate in Lung Cancer Cells: A Comparative Study in vivo and in vitro. Carcinogenesis. 31(5):902-10.
• Dong, P.; Qiu, P.; Zhu, Y.; Li, S.M.; Ho, C.T.; and Xiao, H. (2010) Simultaneous Determination of Four 5-Hydroxy Polymethoxyflavones by reversed-phase high performance liquid chromatograph with electrochemical detection. Journal of Chromatography A. 29;1217(5):642-7
• Hu, M.; Decker, E.A.; Xiao, H.; and McClements, D.J. (2010) Influence of Tripolyphosphate Cross-Linking on the Physical Stability and Lipase Digestibility of Chitosan-Coated Lipid Droplets. J Agric Food Chem. 27;58(2):1283-9.
• Li, S.M., Wang, Y., Wang, Z.Y., Xiao, H., Rawson, N., and Ho, C.T., (2009) Quantitative analysis of hydroxylated polymethoxyflavones by high performance liquid chromatography. Biomed. Chromatogr. (in press)
• Xiao, H., (2009) Potential enhancement of cancer inhibition by using statins in combination with pharmacological and dietary agents. Cancer & Chemotherapy Reviews 4(4): 183-92
• Lu, G., Xiao, H., Li, G., Chen, Y.K., Hao, H., Loy, S., and Yang, C.S. (2009) g-Tocopherol-rich mixture of tocopherols inhibits chemically-induced lung tumorigenesis in A/J mice and xenograft tumor growth. Carcinogenesis (Accepted).
• Li, Yan; Le Maux, S; Xiao, H., McClements, D., Emulsion-based delivery systems for tributyrin: a potential cancer preventive agents. Journal of Agriculture and Food Chemistry 57, 9243-9249.
• Xiao, H., Advances in the use of animal models for intestinal cancers and protective effects of dietary components, in “Designing functional foods: understanding, measuring and controlling food structure breakdown and nutrient absorption for the development of health-promoting foods”, Editor: David J. McClements and Eric A. Decker, 2009Woodhead Publishing Oxford.
• Yang, Z. Xiao, H., Jin, H., Tsang, D., Koo, P. and Yang, C.S.. (2009) Synergistic Actions of Atorvastatin with γ-Tocotrienol and Celecoxib against Human Colon Cancer HT29 and HCT116 Cells. International Journal of Cancer, 126(4):852-63
• Xiao, H., Yang, C.S., Li, S., Jin, H., Ho, C., and Patel, T. (2009) Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung carcinoma cells by apoptosis. Molecular Nutrition and Food Research, 53(3): 398-406.
• Ju, J., Hao, X., Lee, M.J., Lambert, J., Lu, G., Xiao, H., Newmark, H., and Yang, C.S. (2009) gamma-Tocopherol-rich mixed tocopherols inhibit colon tumorigenesis in azoxymethane and dextran sulfate sodium-treated mice. Cancer Prevention Research, 2(2):143-52.
• Liu, Y., Ju, J., Xiao, H., Simi, B., Hao, X., Reddy, B.S., Huang, M.T., Newmark, H. and Yang, C.S. (2008) Effects of combination of calcium and aspirin on azoxymethane-induced aberrant crypt foci formation in the colons of mice and rats. Nutrition and Cancer, 60(5):660-5.
• Xiao, H., and Yang, C.S. (2008) Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention. International Journal of Cancer, 123(5):983-90.
• Liu, Y., Xiao, H., Hao, X., Lee, H.J., Suh, N., Yang, C.S., Minden, A. (2008) The Pak4 protein is overproduced in tumors, and causes tumorigenesis in mice. Molecular Cancer Research 6(7):1215-24.
• Xiao, H., Hao, X., Simi, B., Jiang, H., Ju, J., Reddy, B., and Yang, C.S. (2008) Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats. Carcinogenesis 29(1): 113-9.
• Xiao, H., Zhang, Q., Lin, Y., Reddy, B., and Yang, C.S. (2008) Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. International Journal of Cancer 122(9):2115-24.
• Lu, G., Xiao, H. (Co-first author), You, H., Lin, Y. Snagaski, B., and Yang, C.S. (2008) Synergistic inhibition of lung tumorigenesis by a combination of green tea polyphenols (PPE) and atorvastatin. Clinical Cancer Research, 14(15):4981-8.
• Yang, C.S., Ju, J., Lu, G., Xiao, H., Hao, X., Sang, S., and Lambert, J. (2008) Cancer prevention by tea and tea polyphenols. Asian Pacific Journal of Clinical Nutrition 17 Suppl 1:245-8.
• Xiao, H. and Parkin, K.L. (2007) Isolation and identification of potential chemopreventive agents from methonalic extract of green onion (Allium spp.) guided by phase II enzyme bioassay. Phytochemistry 68(7):1059-67.
• Suh, N., Paul S., Hao, X., Simi, B., Xiao, H., Ramando, A.M. and Reddy, B.S. (2007) Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clinical Cancer Research 13(1):350-5.
• Xiao, H. and Parkin, K.L. (2006). Phase II enzyme induction by various selenium compounds. Nutrition and Cancer. 55:210-223.
• Xiao, H. and Parkin, K.L. (2006). Isolation and identification of potential chemopreventive agents from non-polar extracts of green onion (Allium spp.) guided by phase II enzyme bioassay. J. Agric. Food Chem. 54(22):8417-24.
