Dr. Wolf's current research focuses on restoration of upper extremity function following stroke. His research team is conducting an NIH-funded randomized national clinical trial (EXCITE, the Extremity Constraint-Induced Therapy Evaluation) to explore the effect of constraint-induced movement therapy of the hemiplegic upper extremity on recovery of movement function among patients who have sustained a stroke. Further areas of Dr. Wolf's research include: biomechanical changes in upper extremity motor control following stroke; the effects of direct motor cortical stimulation and intense upper extremity therapy on functional improvement among patients with stroke; the mechanisms underlying possible massed practice cortical reorganization using constraint-induced therapy; changes in behavior among patients and their caregivers when exposed to functionally-based therapeutic interventions; and the effects of robotic assistance on procurement of upper extremity function among patients with stroke.