The University of Massachusetts Amherst

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Vincent Rotello

Goessmann Professor of Chemistry

Our research encompasses multiple applications of nanomaterials in therapeutics and diagnostics, including both nanoparticles and nano/micropatterned surfaces.

Current Research
We are currently developing a range of platforms for next-generation diagnostics. We have created array-based sensing strategies for geno/phenotyping tumors for personalized medicine, and are currently testing this approach using clinical samples. We are also developing paper-based diagnostics for multiple health-related issues. In one project we are working with partners in Pakistan to fabricate very inexpensive and easy to use test strips for detection of pathogens in drinking water. We are also developing test strip/lateral flow platforms for biofluid (serum, urine and perspiration) analysis.

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Academic Background

  • BSc (Honors) Illinois Institute of Technology, 1985
  • MPhil Yale University, 1987
  • PhD Yale University, 1990
  • Postdoctoral Training: NSF Postdoctoral Fellowship MIT, 1990
Liu, Q.; Yeh, Y. C.; Rana, S.; Jiang, Y.; Guo, L.; Rotello, V. M. "Differentiation of cancer cell type and phenotype using quantum dot-gold nanoparticle sensor arrays" Cancer Lett. 2013, 334, 196-201.
Engel, Y.; Schiffman, J. D.; Goddard, J. M.; Rotello, V. M. "Nanomanufacturing of Biomaterials" Mater. Today 2012, 15, 478-485.
Li, X. N.; Wen, F.; Creran, B.; Jeong, Y. D.; Zhang, X. R.; Rotello, V. M. "Colorimetric Protein Sensing Using Catalytically Amplified Sensor Arrays" Small 2012, 8, 3589-3592.
Rana, S.; Singla, A. K.; Bajaj, A.; Elci, S. G.; Miranda, O. R.; Mout, R.; Yan, B.; Jirik, F. R.; Rotello, V. M. "Array-Based Sensing of Metastatic Cells and Tissues Using Nanoparticle-Fluorescent Protein Conjugates" ACS Nano 2012, 6, 8233-8240.
Subramani, C.; Cengiz, N.; Saha, K.; Gevrek, T. N.; Yu, X.; Jeong, Y.; Bajaj, A.; Sanyal, A.; Rotello, V. M. "Direct Fabrication of Functional and Biofunctional Nanostructures Through Reactive Imprinting", Adv. Mater., 2011, 23, 3165-3168.
Miranda, O. R.; Li, X. N.; Garcia-Gonzalez, L.; Zhu, Z. J.; Yan, B.; Bunz, U. H. F.; Rotello, V. M. "Colorimetric Bacteria Sensing Using a Supramolecular Enzyme-Nanoparticle Biosensor" J. Am. Chem. Soc., 2011, 133, 9650-9653.
Landis, R. F.; Li, C. H.; Gupta, A.; Lee, Y. W.; Yazdani, M.; Ngernyuang, N.; Altinbasak, I.; Mansoor, S.; Khichi, M. A. S.; Sanyal, A.; Rotello, V. M., Biodegradable Nanocomposite Antimicrobials for the Eradication of Multidrug-Resistant Bacterial Biofilms without Accumulated Resistance. J. Am. Chem. Soc. 2018, 140, 6176-6182.
Ray, M.; Lee, Y. W.; Hardie, J.; Mout, R.; Tonga, G. Y.; Farkas, M. E.; Rotello, V. M. "CRISPRed Macrophages for Cell-Based Cancer Immunotherapy" Bioconjugate Chem. 2018, 29, 445-450.
Gupta, A.; Das, R.; Tonga, G. Y.; Mizuhara, T.; Rotello, V. M. "Charge-Switchable Nanozymes for Bioorthogonal Imaging of Biofilm-Associated Infections" ACS Nano 2018, 12, 89-94.
Le, N. D. B.; Tonga, G. Y.; Mout, R.; Kim, S. T.; Wille, M. E.; Rana, S.; Dunphy, K. K.; Jerry, D. J.; Yazdani, M.; Ramanathan, R.; Rotello, C. M.; Rotello, V. M. "Cancer Cell Discrimination Using Host-Guest "Doubled" Arrays" J. Am. Chem. Soc. 2017, 139, 8008-8012.
Mout, R.; Ray, M.; Tay, T.; Sasaki, K.; Tonga, G. Y.; Rotello, V. M. "General Strategy for Direct Cytosolic Protein Delivery via Protein-Nanoparticle Co-engineering" ACS Nano 2017, 11, 6416-6421.
Tang, R.; Wang, M.; Ray, M.; Jiang, Y.; Jiang, Z. W.; Xu, Q. B.; Rotello, V. M. "Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags" J. Am. Chem. Soc. 2017, 139, 8547-8551.
Mout, R.; Ray, M.; Tonga, G. Y.; Lee, Y. W.; Tay, T.; Sasaki, K.; Rotello, V. M. "Direct Cytosolic Delivery of CRISPR/Cas9-Ribonucleoprotein for Efficient Gene Editing" ACS Nano 2017, 11, 2452-2458.
Moyano, D. F.; Liu, Y. C.; Ayaz, F.; Hou, S.; Puangploy, P.; Duncan, B.; Osborne, B. A.; Rotello, V. M. "Immunomodulatory Effects of Coated Gold Nanoparticles in LPS-Stimulated In Vitro and In Vivo Murine Model Systems" Chem 2016, 1, 9.
Jiang, Y.; Wang, M.; Hardie, J.; Tonga, G. Y.; Ray, M.; Xu, Q. B.; Rotello, V. M. "Chemically Engineered Nanoparticle-Protein Interface for Real-Time Cellular Oxidative Stress Monitoring" Small 2016, 12, 3775-3779.
Saha, K.; Rahimi, M.; Yazdani, M.; Kim, S. T.; Moyano, D. F.; Hou, S.; Das, R.; Mout, R.; Rezaee, F.; Mahmoudi, M.; Rotello, V. M. "Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona" ACS Nano 2016, 10, 4421-4430.

Our research encompasses multiple applications of nanomaterials in therapeutics and diagnostics, including both nanoparticles and nano/micropatterned surfaces.

Contact Info

Department of Chemistry
379A Lederle Graduate Research Center
740 North Pleasant Street
Amherst, MA 01003

(413) 545-2058