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| R.
THOMAS ZOELLER |
Bio |
Research |
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Thyroid hormone is essential for normal brain
development. The main focus of research in
the laboratory is to understand the molecular
mechanism(s) by which thyroid hormone affects
brain development and brain function. We pursue
this goal within the context of two large
projects. First, we are cloning genes expressed
in the fetal brain that are regulated by maternal
thyroid hormone. These genes have led us to
examine the effect of thyroid hormone on cortical
cell proliferation, differentiation and fate
specification. Second, we are examining the
mechanisms by which thyroid hormone action
can be disrupted by polychlorinated biphenyls
(PCBs). These chemicals are structurally similar
to thyroid hormone. PCBs are known to affect
neural development and they can alter circulating
levels of thyroid hormone.
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