PROGRAM COURSES - DRUG DESIGN 2004

Biochm/Chem 597A, Fall 2004 (3 credits)

Professors:

Lila Gierasch (Chemistry & Biochemistry and Molecular Biology, 814 LGRT, gierasch@biochem.umass.edu)
Joanna Swain (Biochemistry and Molecular Biology, 604 LGRT, swain@biochem.umass.edu)

Class Meeting Time/Place:

Mondays 4:00-5:15 PM; Room 101 LGRT
Thursdays 1:00-2:15 PM; Room 1634 LGRT

Schedule:

DAY DATE LECTURER TOPIC
Th 9/9/04 Lila Gierasch and Joanna Swain Introduction to course; background on drug-receptor interactions
M 9/13/04 Discussion Continuation
Th 9/16/04 Sherin Abdel-Meguid, Consultant Target Selection
M 9/20/04 Discussion  
Th 9/23/04 Chris Lipinski, Pfizer Inc. Making leads into drugs
M 9/27/04 Discussion  
Th 9/30/04 Angela Cacace, Bristol-Myers Squibb HTS assay development
M 10/4/04 Discussion  
Th 10/7/04

Discussion

 
M 10/11/04 Columbus Day - Holiday  
W 10/13/04 Mark Wentland, RPI

HTS and combinatorial chemistry
Wednesday, following Monday class schedule

Th 10/14/04 Jonathan Greer, Abbott Laboratories Structure-based drug design in drug discovery
M 10/18/04 Discussion  
Th 10/21/04 Jotham Coe, Pfizer, Inc. Nicotine meets its match
M 10/25/04 Mark Murcko, Vertex Pharmaceuticals Inc. Chemogenomics and In Silico ADME/Tox
Th 10/28/04 Discussion  
M 11/1/04 Scott Weiss, Harvard Medical School Pharmacogenomics/Asthma
Th 11/4/04 Discussion  
M 11/8/04 Chris Walsh, Harvard Medical School Antibiotics: past, present and future
Th 11/11/04 Veterans Day - Holiday  
M 11/15/04 Discussion  
Th 11/18/04 Tour of AstraZeneca Waltham, MA
M 11/22/04 Discussion Monday, following Thurs. schedule
Th 11/25/04 Thanksgiving - Holiday  
M 11/29/04 John Talley, Microbia, Inc. Discovery of COX-2 Inhibitors
Th 12/2/04 Discussion  
M 12/6/04 Discussion  
Th 12/9/04 Jean Lachowicz, Schering-Plough GPCR case study
M 12/13/04 Discussion