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PROGRAM COURSES - DRUG DESIGN 2004
Biochm/Chem 597A, Fall 2004 (3 credits)
Professors:
Lila Gierasch (Chemistry & Biochemistry
and Molecular Biology, 814 LGRT, gierasch@biochem.umass.edu)
Joanna Swain (Biochemistry and Molecular Biology, 604
LGRT, swain@biochem.umass.edu)
Class Meeting Time/Place:
Mondays 4:00-5:15 PM; Room 101 LGRT
Thursdays 1:00-2:15 PM; Room 1634 LGRT
Schedule:
| DAY |
DATE |
LECTURER |
TOPIC |
| Th |
9/9/04 |
Lila Gierasch and Joanna Swain |
Introduction to course; background on drug-receptor interactions |
| M |
9/13/04 |
Discussion |
Continuation |
| Th |
9/16/04 |
Sherin Abdel-Meguid, Consultant |
Target Selection |
| M |
9/20/04 |
Discussion |
|
| Th |
9/23/04 |
Chris Lipinski, Pfizer Inc. |
Making leads into drugs |
| M |
9/27/04 |
Discussion |
|
| Th |
9/30/04 |
Angela Cacace, Bristol-Myers Squibb |
HTS assay development |
| M |
10/4/04 |
Discussion |
|
| Th |
10/7/04 |
Discussion
|
|
| M |
10/11/04 |
Columbus Day - Holiday |
|
| W |
10/13/04 |
Mark Wentland, RPI |
HTS and combinatorial chemistry
Wednesday, following Monday class schedule
|
| Th |
10/14/04 |
Jonathan Greer, Abbott Laboratories |
Structure-based drug design in drug discovery |
| M |
10/18/04 |
Discussion |
|
| Th |
10/21/04 |
Jotham Coe, Pfizer, Inc. |
Nicotine meets its match |
| M |
10/25/04 |
Mark Murcko, Vertex Pharmaceuticals Inc. |
Chemogenomics and In Silico ADME/Tox |
| Th |
10/28/04 |
Discussion |
|
| M |
11/1/04 |
Scott Weiss, Harvard Medical School |
Pharmacogenomics/Asthma |
| Th |
11/4/04 |
Discussion |
|
| M |
11/8/04 |
Chris Walsh, Harvard Medical School |
Antibiotics: past, present and future |
| Th |
11/11/04 |
Veterans Day - Holiday |
|
| M |
11/15/04 |
Discussion |
|
| Th |
11/18/04 |
Tour of AstraZeneca |
Waltham, MA |
| M |
11/22/04 |
Discussion |
Monday, following Thurs. schedule |
| Th |
11/25/04 |
Thanksgiving - Holiday |
|
| M |
11/29/04 |
John Talley, Microbia, Inc. |
Discovery of COX-2 Inhibitors |
| Th |
12/2/04 |
Discussion |
|
| M |
12/6/04 |
Discussion |
|
| Th |
12/9/04 |
Jean Lachowicz, Schering-Plough |
GPCR case study |
| M |
12/13/04 |
Discussion |
|
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