The University of Massachusetts Amherst

Wei Cui

Extension Assistant Professor, Director of Animal Models Core

Research areas include mammalian oocyte maturation and activation, preimplantation embryo development, micromanipulation and animal model generation.

Current Research

Current research in my laboratory aims at: 1) understanding the cellular and molecular mechanisms underlying mammalian oocyte meiosis, activation, and aging; 2) discovering novel genes, factors, and signaling pathways that are functionally required during mammalian preimplantation embryo development; 3) creating animal models of human genetic diseases using knock-out, knock-in, and transgenesis strategies.

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Academic Background

  • Postdoctoral Training, University of Massachusetts Amherst, 2014-2017
  • Postdoctoral Training, University of Kansas Medical Center, 2013-2014
  • Ph.D, Shandong Agricultural University, China, 2013
Cui W, Marcho C, Wang Y, Degani R, Golan M, Tremblay KD, Rivera-Perez J, Mager J. MED20 is essential for early embryogenesis and regulates NANOG expression. Reproduction 2019;157(3): 215–222. PMC6545164
Cui W, Mager J. Chapter: Transcriptional Regulation and Genes Involved in First Lineage Specification During Preimplantation Development. Chromatin Regulation of Early Embryonic Lineage Specification 2018; 31-46. PMID: 29177763
Cui W, Dai X, Marcho C, Han Z, Zhang K, Tremblay KD, Mager J. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Scientific Reports 2016; 6, 37396; doi: 10.1038/srep37396. PMC5116644
Chakraborty D, Cui W, Rosario GX, Scott RL, Dhakal P, Renaud SJ, Tachibana M, Rumi MA, Mason CW, Krieg AJ, Soares MJ. HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia. Proc Natl Acad Sci USA 2016; pii:201612626 PMC5135375
Cui W, Pizzollo J, Han Z, Marcho C, Zhang K, Mager J. Nop2 is required for mammalian preimplantation development. Mol Reprod Dev 2016; 83(2):124-131 (Cover). PMC4903073
Kubota K, Cui W, Dhakal P, Wolfe MW, Rumi MA, Vivian JL, Roby KF, Soares MJ. Rethinking progesterone regulation of female reproductive cyclicity. Proc Natl Acad Sci USA 2016; 113(15):4212-7. PMC4839436
Cui W, Zhang J, Zhang CX, Jiao GZ, Zhang M, Wang TY, Luo MJ, Tan JH. Control of spontaneous activation of rat oocytes by regulating plasma membrane Na+/Ca2+ exchanger activities. Biol Reprod 2013; 88(6):160. PMID: 23677981
Cui W, Zhang J, Lian HY, Wang HL, Miao DQ, Zhang CX, Luo MJ, Tan JH. Roles of MAPK and Spindle Assembly Checkpoint in Spontaneous Activation and MIII Arrest of Rat Oocytes. PLoS One 2012; 7:e32044. PMC3288063
Contact Info

Department of Veterinary & Animal Sciences
S521 Life Science Laboratories
240 Thatcher Way
Amherst, MA 01003-9292

(413) 545-0673