Our research encompasses multiple applications of nanomaterials in therapeutic delivery for both mammalian and microbial targets.
We have developed a set of delivery vectors that employ a novel membrane fusion process to provide direct delivery of proteins and nucleic acids directly to the cell cytosol. This process avoids the challenges of endosomal entrapment, providing much more efficient delivery than standard systems. We have used these vectors for siRNA delivery for anti-inflammatory applications. We have also applied these systems to highly effective Cas9/guide RNA delivery for CRISPR editing both in vitro and systemically in vivo.
Concurrect with our mammalian work, we have created highly effective nanotherapeutics against wound biofilms. These systems combine biofilm-penetrating polymers with naturally-occurring essential oils to penetrate and eradicate biofilms in vitro and in vivo.
Learn more at elements.chem.umass.edu/rotellogroup/
- BSc (Honors) Illinois Institute of Technology, 1985
- MPhil Yale University, 1987
- PhD Yale University, 1990
- Postdoctoral Training: NSF Postdoctoral Fellowship MIT, 1990