In our research we use experimental and computational methods to understand the cellular mechanisms that give rise to drug resistance in tumors and we use engineering methods to design therapeutic strategies to overcome resistance in tumors.
To date the major advances of our group have been:
- determination of the mechanisms that control the localization of therapeutic bacteria in tumors;
- development of therapeutic bacteria that secrete an anti-cancer protein and dramatically increase survival in mice;
- quantification of the effects of spatial heterogeneity on tumor metabolism, cell survival, and cell cycle progression;
- development of computation tools to analyze the interactions of therapeutics with tumors; and
- demonstration that the properties of nanoparticles can be tuned to enhance tumor targeting.
Learn more at www.ecs.umass.edu/~forbes/
- BS Case Western Reserve University, 1994
- PhD University of California at Berkeley, 2000
- Postdoctoral Training: Harvard Medical School
Toley BJ, Forbes NS. 2012. Motility is critical for effective distribution and accumulation of bacteria in tumor tissue. Integr. Biol. 4:165-76