The University of Massachusetts Amherst

Guodong Zhang

Assistant Professor

Research areas include

Current Research
My research focuses on actions and mechanisms of lipid autacoids on angiogenesis, inflammation and cancer. These research efforts will elucidate the mechanisms for the health modulating effects of dietary lipids, facilitating the development of better nutritional paradigms and clinical trials to clarify the effects of dietary lipids. In addition, the identified endogenous lipid autacoids could serve as biotemplates to design more potent and safer therapeutics.

Learn more at sites.google.com/site/guodongzhanglab/home

Academic Background

  • BS Xi'an Jiaotong University, China, 1999-2003
  • MS National University of Singapore, Singapore, 2003-2005
  • PhD University of Wisconsin Madison, 2005-2010
  • Postdoctoral Training: University of California Davis, 2010-2013
Yang H.*, Wang W.*, Romano K.A., Gu M., Sanidad K., Kim D., Yang J., Schmidt B., Panigrahy D., Pei R., Martin D.A., Ozay E.I., Wang Y., Song M., Bolling B.W., Xiao H., Minter L.M., Yang G., Liu Z., Rey F.E.(#), and Zhang G.(#). (2018) A common antimicrobial additive increases colonic inflammation and colon tumorigenesis in mice. Science Transnational Medicine 10:eaan4116. doi: 10.1126/scitranslmed.aan4116.
Wang W.*, Yang J.*, Zhang J.*, Wang Y., Hwang S., Qi W., Wan D., Sun J., Sanidad K., Yang H., Park Y., Liu J., Liu Z., Hammock B.D.(#) and Zhang G.(#). (2018) Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. Proceedings of the National Academy of Sciences 115:5283-5288.
Sanidad K.*, Yang H.*, Wang W., Ozay E., Yang J., Gu M., Karner M., Zhang J., Kim D., Minter L., Xiao H., and Zhang G.(#) (2018) Effects of consumer antimicrobials benzalkonium chloride, benzethonium chloride, and chloroxylenol on colonic inflammation and colitis-associated colon tumorigenesis in mice. Toxicological Sciences 163:490–499.
Sanidad K.Z.*, Sukamtoh E.*, Xiao H., McClements D.(#) and Zhang G.(#). (2018) Curcumin: Recent Advances in the Development of Strategies to Improve Oral Bioavailability. Submitted to Annual Review of Food Science and Technology (invited contribution).
Wang Y., Wang W., Sanidad K., Shih P., Zhao X., and Zhang G.(#). (2018) Eicosanoid signaling in carcinogenesis of colorectal cancer. Cancer Metastasis Review doi: 10.1007/s10555-018-9739-8.
Wang W.*, Yang J.*, Nimiya Y., Lee K., Sanidad K., Qi W., Sukamtoh E., Park Y., Liu, Z., and Zhang G.(#) (2017) ω-3 polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice. Journal of Nutritional Biochemistry 48:29-35.
Wang W.*, Yang J.*, Qi W., Yang H., Wang C., Tan B., Hammock B.D., Park Y., Kim D., and Zhang G.(#) (2017) Lipidomic profiling of high-fat diet-induced obesity in mice: importance of cytochrome P450-derived fatty acid epoxides. Obesity, 25, 132-140.
Nimiya Y.*, Wang W.*, Du Z., Sukamtoh E., Zhu J., Decker E. and Zhang G.(#) (2016) Redox modulation of curcumin stability: redox active antioxidants increase chemical stability of curcumin. Molecular Nutrition & Food Research 60:487-94.
 
Contact Info

Department of Food Science
245 Chenoweth Laboratory
100 Holdsworth Way
Amherst, MA 01003

(413) 545-1014
guodongzhang@umass.edu

sites.google.com/site/guodongzhanglab/home