Guodong Zhang
Associate Professor
Current Research
Our research focuses on prevention of colonic inflammation (inflammatory bowel disease) and colon cancer. To achieve this, we address two major issues: (1) identification and characterization of novel environmental risk factors of IBD and colon cancer. We study how environmental and dietary compounds alter gut microbiome and deregulate mucosa immune system to exaggerate colonic inflammation and colon tumorigenesis; and (2) discovery of novel therapeutic targets and biomarkers of IBD and colon cancer. We use LC-MS/MS-based lipidomics and transgenic animal models to study the roles of eicosanoid signaling in colonic inflammation and colon cancer, in order to identify novel therapeutic targets and biomarkers of these diseases.
Learn more at sites.google.com/site/guodongzhanglab/home
Academic Background
- BS Xi'an Jiaotong University, China, 1999-2003
- MS National University of Singapore, Singapore, 2003-2005
- PhD University of Wisconsin Madison, 2005-2010
- Postdoctoral Training: University of California Davis, 2010-2013
Wang Y., Yang J., Wang W., Sanidad K.Z., Cinelli M.A., Wan D., Hwang S.H., Kim D., Lee K.S.S., Xiao H., Hammock B.D., and Zhang G. (2020) Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation. PNAS 117: 8431-8436.
Yang H., Sanidad K.Z., Wang W., Xie M., Gu M., Cao X., Xiao H., and Zhang G. (2019) Triclocarban exposure exaggerates colonic inflammation and colon tumorigenesis: roles of gut microbiota involved. Gut Microbes 24:1-12. Doi: 10.1080/19490976.2019.1690364.
Wang W., Yang J., Edin M.L., Wang Y., Luo Y., Wan D., Yang H., Sanidad K.Z., Song M., Bisbee A.H., Bradbury J.A., Nan G., Zhang J., Shih B., Lee K.S.S., Minter L.M., Kim D., Xiao H., Liu J., Hammock B.D., Zeldin D.C., and Zhang G. (2019) Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as novel therapeutic target of colon tumorigenesis. Cancer Research 79:1822-1830.
Wang W., Yang J., Zhang J., Wang Y., Hwang S., Qi W., Wan D., Kim D., Sun J., Sanidad K.Z., Yang H., Park Y., Liu J., Liu Z., Hammock B.D. and Zhang G. (2018) Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. PNAS 115:5283-5288.
Yang H., Wang W., Romano K.A., Gu M., Sanidad K., Kim D., Yang J., Schmidt B., Panigrahy D., Pei R., Martin D.A., Ozay E.I., Wang Y., Song M., Bolling B.W., Xiao H., Minter L.M., Yang G., Liu Z., Rey F.E., and Zhang G. (2018) A common antimicrobial additive increases colonic inflammation and colon tumorigenesis in mice. Science Translational Medicine 10:eaan4116. Doi: 10.1126/scitranslmed.aan4116.
Yang H.*, Wang W.*, Romano K.A., Gu M., Sanidad K., Kim D., Yang J., Schmidt B., Panigrahy D., Pei R., Martin D.A., Ozay E.I., Wang Y., Song M., Bolling B.W., Xiao H., Minter L.M., Yang G., Liu Z., Rey F.E.(#), and Zhang G.(#). (2018) A common antimicrobial additive increases colonic inflammation and colon tumorigenesis in mice. Science Transnational Medicine 10:eaan4116. doi: 10.1126/scitranslmed.aan4116.
Wang W.*, Yang J.*, Zhang J.*, Wang Y., Hwang S., Qi W., Wan D., Sun J., Sanidad K., Yang H., Park Y., Liu J., Liu Z., Hammock B.D.(#) and Zhang G.(#). (2018) Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. Proceedings of the National Academy of Sciences 115:5283-5288.
Sanidad K.*, Yang H.*, Wang W., Ozay E., Yang J., Gu M., Karner M., Zhang J., Kim D., Minter L., Xiao H., and Zhang G.(#) (2018) Effects of consumer antimicrobials benzalkonium chloride, benzethonium chloride, and chloroxylenol on colonic inflammation and colitis-associated colon tumorigenesis in mice. Toxicological Sciences 163:490–499.
Sanidad K.Z.*, Sukamtoh E.*, Xiao H., McClements D.(#) and Zhang G.(#). (2018) Curcumin: Recent Advances in the Development of Strategies to Improve Oral Bioavailability. Submitted to Annual Review of Food Science and Technology (invited contribution).
Wang Y., Wang W., Sanidad K., Shih P., Zhao X., and Zhang G.(#). (2018) Eicosanoid signaling in carcinogenesis of colorectal cancer. Cancer Metastasis Review doi: 10.1007/s10555-018-9739-8.
Wang W.*, Yang J.*, Nimiya Y., Lee K., Sanidad K., Qi W., Sukamtoh E., Park Y., Liu, Z., and Zhang G.(#) (2017) ω-3 polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice. Journal of Nutritional Biochemistry 48:29-35.
Wang W.*, Yang J.*, Qi W., Yang H., Wang C., Tan B., Hammock B.D., Park Y., Kim D., and Zhang G.(#) (2017) Lipidomic profiling of high-fat diet-induced obesity in mice: importance of cytochrome P450-derived fatty acid epoxides. Obesity, 25, 132-140.
Nimiya Y.*, Wang W.*, Du Z., Sukamtoh E., Zhu J., Decker E. and Zhang G.(#) (2016) Redox modulation of curcumin stability: redox active antioxidants increase chemical stability of curcumin. Molecular Nutrition & Food Research 60:487-94.
