Research areas include biology and neogenesis of human and mouse pancreatic islets and beta cells, diabetes/metabolism and glucose homeostasis, reproduction, infertility, and premature ovarian failure. In 2014 Dr. Schneyer co-founded Fairbanks Pharmaceuticals (www.fairbankspharma.com) to pursue potential therapeutic ideas based on these research findings. The company’s research lab is located in Springfield at the Baystate Research Facility and many of the employees are UMass graduates. Fairbanks has been funded largely by Phase I and II SBIR grants. We have developed monoclonal antibodies that neutralize FSTL3 which we hypothesize will mimic the FSTL3 KO mice in producing enhanced beta cell function and transdifferentiation of new beta cells. In vitro this FSTL3 neutralizing antibody can restore function in diabetic islets and we are now testing it in vivo in mouse models of diabetes.
My research group is focused on identification of new sources for pancreatic beta cells through regeneration and reprogramming. We have identified growth factors that control formation of new beta cells from other islet cells. Therapeutics based on this research, such as neutralizing antibodies, are being explored as treatments for both type 1 and type 2 diabetes.
Activin is a growth factor in the TGFbeta superfamily that is regulated by antagonists such as follistatin like-3 (FSTL3). FSTL3 knockout mice have enlarged islets with more beta cells and improved glucose homeostasis. We determined that these extra beta cells do not arise from proliferation, but rather appear to form via conversion of other islet cells types, mainly alpha cells. While the mechanisms for this type of conversion are a major area of research, we found that KO mice have more of these converted beta cells than wild type mice suggesting that the process is both normal and enhanced by activin. This suggests that treatments which inhibit FSTL3 or enhance activin might be useful as novel therapies for diabetes where replacement of lost beta cells is essential.
Learn more at www.vasci.umass.edu/research-faculty/alan-l-schneyer
- BS University of Pennsylvania, 1976
- MS University of Miami, 1980
- PhD University of Miami, 1983
- Postdoctoral Training: Albany Medical College, 1984-1986