Develop and utilize novel delivery technologies to modify cells that are used for a variety of therapies. Examples include ongoing work to modify bacteria to invade tumor tissue and deliver payloads designed to kill or arrest the growth of the tumor. Additionally, strategies are being developed to use delivery technologies to modify cells of the immune system for adoptive transfer into a syngeneic host. The aim is to develop efficient ex vivo approaches to manipulating cellular responses and utilize them in a variety of therapeutic approaches.
How many active caspases does it take to induce apoptosis? Do pro-survival and pro-apoptotic intracellular balances influence a caspase’s ability to induce cell death (i.e. potency)?
Cysteine aspartate proteases (caspases) act as the molecular scissors of apoptotic cell death, disintegrating diverse cellular components necessary for cell survival and growth.