Stratton Lab develops biosensor for CaMKII protein

Researchers from the Stratton Lab in BMB have teamed up with colleagues in Animal Science and Biology to create a biosensor, called FRESCA, that monitors whether the CaMKII protein is on or off. CaMKII is important for long-term memory formation, maintaining heart rhythm, and fertilization. FRESCA (FRET Sensor for CaMKII Activity) changes color when the CaMKII protein turns on, which allows researchers to watch what CaMKII is doing in different cell types under different conditions. Aiding the study of this protein is vital, as mutations in CaMKII can lead to brain dysfunction (such as Alzheimer's Disease and autism), cardiac dysfunction (such as arrhythmia), and infertility.